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Light-gated ion channel : ウィキペディア英語版 | Light-gated ion channel Light-gated ion channels are a group of transmembrane proteins that form ion channels; pores which open or close in response to light. Most light-gated ion channels have been synthesized in the laboratory for study, though one naturally occurring example, Channelrhodopsin, is currently known.〔("Engineering Light-Gated Ion Channels" ) — ''Biochemistry'', 45 (51), 15129 -15141, 2006〕 Photoreceptor proteins, which act in a similar manner to light-gated ion channels are generally G protein-coupled receptors and not actually gated ion channels. == Synthetic purpose == Other types of gated ion channels, ligand-gated and voltage-gated, have been synthesized with a light-gated component in an attempt to better understand their nature and properties. By the addition of a light-gated section, the kinetics and mechanisms of operation can be studied in depth. For example, the addition of a light-gated component allows for the introduction of many highly similar ligands to be introduced to the binding site of a ligand-gated ion channel to assist in the determination of the mechanism. In 1980, the first ion channel to be adapted for study with a light-gated mechanism was the nicotinic acetylcholine receptor.〔("A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques" ) — The Journal of General Physiology, Vol 75, 207-232〕 This receptor was well-known at the time, and so was aptly suited to adaptation, and allowed for a study of the kinetics as not allowed before.
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